No. 09
Taiho VenturesTaiho Ventures
Issue Nine · The Syndicate Edition

Patient Capital,First-In-ClassScience.

A small institutional fund inside a Japanese pharma. Three areas — oncology, immunology, urology. Research through proof-of-concept. Co-investing with the firms that lead.

Vol. IXSpring 2026$0Founded 2016

01 — Letter from the Partners

A note on what we mean when we say strategic syndicate partner

We are a CVC, but the way we operate looks more like a small institutional fund.

We started in 2016 with a single mandate from our parent company: invest in the science Taiho Pharmaceutical needs to be reading about a decade from now. Two hundred million dollars under management at the time, four hundred million today. Five investors on the team. Twenty-three companies on the cap table.

We are not the lead. We almost never lead. We come in early — research to proof-of-concept — alongside the firms running the round, and we add what those firms generally cannot: a credible global pharma partner sitting at the table, asking the kind of development questions a real partner would ask in year five.

Patient capital is not a marketing line for us. Our parent does not need this fund to clear a seven- to ten-year window, and that fact changes the kind of science we can back. It also changes the kind of conversation we can have with founders about timing, modality risk, and what the second program looks like before the first one has cleared Phase I.

Sakae AsanumaPresident & CEO, Taiho Ventures· Menlo Park, CA

02 — Portfolio

On the cap table

Twenty-three companies. Three therapeutic areas. One thesis.

Selected companies from the active book. Captioned by area, modality, and clinical stage as of the most recent disclosure. Photography is from site visits and partner-led shoots; we do not use stock imagery.

Cullinan Therapeutics — wet-lab bench, Cambridge MA
CULLINAN ONCOLOGY · CAMBRIDGE, MA · 02 · 2026

Feature · Oncology

Cullinan Therapeutics

cullinanoncology.com

Public oncology platform building bispecifics and small-molecule inhibitors against ER+ breast, NSCLC, and AML. We led co-investment alongside MPM and F-Prime in 2018; partnered through the IPO.

Modality
Bispecific antibody · Small molecule
Stage
Phase III
Round
IPO · Nasdaq CGEM
Vintage
2018
Orna Therapeutics — circular RNA synthesis bench
ORNA TX · WATERTOWN, MA · 11 · 2025

Platform · Phase I

Orna Therapeutics

ornatx.com

A circular-RNA platform with potential across oncology, vaccines, and protein replacement. We co-invested in the 2022 round led by MPM and Merck, and the Pfizer collaboration followed within twelve months.

Circular RNA · Series B · 2022

Halda Therapeutics — discovery chemistry
HALDA TX · NEW HAVEN, CT · 01 · 2026

Oncology · Phase I

Halda Therapeutics

haldatx.com

A novel ribosomal-targeting platform with first-in-class small molecules in prostate and breast cancer. Series B in 2024, alongside Canaan and Deep Track.

Small molecule · Series B · 2024

Magnet Biomedicine — high-throughput screen
MAGNET BIO · CAMBRIDGE, MA · 03 · 2026

Oncology

Magnet Biomedicine

magnetbio.com

A molecular-glue discovery platform aimed at transcription factors and other undruggable oncology targets. Co-investment alongside Newpath and Catalio in 2023.

Discovery · Molecular glue

Normunity — translational clinic environment
NORMUNITY · NEW HAVEN, CT · 02 · 2026

Immunology

Normunity

normunity.com

Normunity is decoding the tumor-normal interface to find immunotherapy targets that other platforms miss. We co-invested at Series A in 2021.

Pre-IND · Antibody

Werewolf Therapeutics — protein engineering
WEREWOLF TX · WATERTOWN, MA · 09 · 2025

Immunology

Werewolf Therapeutics

werewolftx.com

A conditionally-active immunotherapy platform — INDUKINE molecules engineered to activate inside the tumor microenvironment, sparing peripheral tissue. Public.

Phase II · Conditionally-active cytokine

03 — The Syndicate

A small group of repeat partners.

We do not lead rounds. We co-invest. The chart below is the active book — firms we have co-invested with on at least two named rounds since 2016, ranked by frequency. Pharma sits next to the dedicated biotech crossover names, which is the kind of cap-table that tends to clear regulatory questions earlier than later.

  • Active book23 cos.
  • Rounds since 201647
  • IPOs / M&A11
  • Lead investors we know24

Who we co-invest with, and how oftenCompiled · Q1 2026 · Source: internal records

  1. 01
    F-Prime CapitalSeries A → B
    7 rounds
  2. 02
    MPM BioImpactSeries A → IPO
    6 rounds
  3. 03
    Canaan PartnersSeries A → B
    5 rounds
  4. 04
    Deep Track CapitalCrossover
    4 rounds
  5. 05
    OrbiMedSeries B → IPO
    4 rounds
  6. 06
    Catalio CapitalSeries A
    4 rounds
  7. 07
    NEASeries B → IPO
    3 rounds
  8. 08
    RA CapitalCrossover
    3 rounds
  9. 09
    Pfizer VenturesStrategic
    2 rounds
  10. 10
    Eli Lilly VenturesStrategic
    2 rounds
  11. 11
    Newpath PartnersSeries A
    2 rounds
  12. 12
    Mubadala CapitalSeries B
    2 rounds

04 — Pull · Folio 22

Patient capitalis not a marketing line.It is a structural fact.
Sakae AsanumaPresident & CEO, Taiho Ventures· BIO International · Boston · 2025

05 — Masthead

On the masthead

Five investors

Photography · L. Tanaka · Menlo Park, CA · March 2026

  • Sakae Asanuma — Menlo Park, CA
    S. ASANUMA · PRESIDENT & CEO

    Sakae Asanuma

    President & CEO

    Founder · 2016

    Astellas Venture Management; Yasuda Enterprise

    CFA · MBA · Menlo Park

  • Seiji Miyahara — Menlo Park, CA
    S. MIYAHARA · PARTNER

    Seiji Miyahara

    Partner & Senior Investment Director

    Joined 2016

    Taiho Pharmaceutical, Oncology R&D, 12 yrs

    PhD · Hokkaido · Menlo Park

  • Takaaki Ishii — Menlo Park, CA
    T. ISHII · SR. INV. DIR.

    Takaaki Ishii

    Senior Investment Director

    Joined 2019

    Taiho Pharmaceutical, Oncology MSL

    Mol. Biology · Menlo Park

  • Hidefumi Kasuga — Menlo Park, CA
    H. KASUGA · INV. DIR.

    Hidefumi Kasuga

    Investment Director

    Joined 2022

    Taiho Pharmaceutical, EGFR Discovery, 9 yrs

    PhD · Univ. Tokyo · Menlo Park

  • Takayuki Hirano — Menlo Park, CA
    T. HIRANO · ASSOC. INV. DIR.

    Takayuki Hirano

    Associate Investment Director

    Joined 2024

    Taiho Pharmaceutical, Non-Clinical Tox, 15 yrs

    PhD · Tokushima · Menlo Park